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Brain-Derived Neurotrophic Factor in the Acute and Early Recovery Period of Ischemic Stroke: The Role of Nocturnal Hypoxemia

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Objective. To study the relationship between the brain-derived neurotrophic factor (BDNF) level and the severity of nocturnal hypoxemia in patients in the acute and early recovery periods of ischemic stroke (IS). Materials and methods. The study included 44 patients (27 men and 17 women) aged 18–85 years in the acute phase of IS. A total of 35 patients (21 men and 14 women) were examined at follow-up three months later. During the acute period, routine diagnostic procedures were supplemented with respiratory monitoring and measurement of serum BDNF levels using an enzyme immunoassay method. BDNF levels were also re-evaluated at outpatient visits three months after IS. Neurological status and changes during the acute period of stroke were assessed as part of routine clinical practice using the National Institutes of Health Stroke Scale (NIHSS) on admission and discharge. Results. Weak direct relationships were found between the durations of hypoxemia and saturation levels (SpO2) of <90% (r = 0.327, p = 0.035) and <85% (r = 0.461, p = 0.003) and the BDNF level in the acute period of IS. BDNF levels in the acute period of IS correlated negatively with the minimum saturation value (r = –0.328, p = 0.034). A direct relationship was also demonstrated between the BDNF level in the early recovery period of IS and the duration of hypoxemia with SpO2 <85% (r = –0.389, p = 0.028). Regression analysis results showed that the minimum saturation level is a predictor of the BDNF level. No signifi cant relationships were found with measures of the severity of sleep-disordered breathing such as the apnea-hypopnea index and desaturation index. Conclusions. The severity of nocturnal hypoxemia is associated with increased BDNF levels in both the acute and recovery periods of ischemic stroke, regardless of the presence of concomitant sleep-disordered breathing.

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Authors and Affiliations

  1. Almazov National Medical Research Center, Russian Ministry of Health, St. Petersburg, Russia

    E. N. Zabroda, V. V. Amelina, A. D. Gordeev, M. V. Bochkarev, E. E. Kayumova, E. Yu. Vasilieva, Yu. V. Sviryaev & L. S. Korostovtseva

  2. St. Petersburg State University, St. Petersburg, Russia

    E. N. Zabroda & A. D. Gordeev

  3. Herzen Russian Sate Pedagogical University, St. Petersburg, Russia

    V. V. Amelina

  4. St. Petersburg Medical and Social Institute, St. Petersburg, Russia

    I. V. Sakovsky

  5. Institute of Biology, a Subdivision of Karelia Science Center, Russian Academy of Sciences, Petrozavodsk, Russia

    S. N. Kolomeichuk

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  1. E. N. Zabroda
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  2. V. V. Amelina
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  4. I. V. Sakovsky
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  7. E. E. Kayumova
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  8. E. Yu. Vasilieva
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  9. Yu. V. Sviryaev
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  10. L. S. Korostovtseva
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Correspondence to E. N. Zabroda.

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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 124, No. 5, Iss. 2, pp. 72–78, May, 2024.

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Zabroda, E.N., Amelina, V.V., Gordeev, A.D. et al. Brain-Derived Neurotrophic Factor in the Acute and Early Recovery Period of Ischemic Stroke: The Role of Nocturnal Hypoxemia. Neurosci Behav Physi (2024). https://doi.org/10.1007/s11055-024-01701-y

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  • DOI: https://doi.org/10.1007/s11055-024-01701-y

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