Advanced local therapies from nano-engineered implants and biomaterials

Nano-engineering of implants and biomaterials is emerging as an ideal strategy to enable local and controlled elution of potent therapeutic molecules to achieve maximized local therapeutic action. Local therapies allow for tailored and customizable treatments for specific conditions, bypassing conventional intravenous drug administration. Further, the next generation of nano-engineered implants are incorporated with responsive/triggered nanoparticles (both synthetic and natural like exosomes), towards their long-term sustained release. Moreover, such systems permit safe delivery of sensitive yet potent molecules like growth factors, directly inside the compromised implant micro-environment. This special issue covers such advanced therapies from the surface of nanoscale modified implants and biomaterials, which would result in a paradigm shift in local customizable therapeutic treatments. The special issue welcomes original research, communications and review articles.