Journal
Discover Oncology
Discover Oncology is an open access journal publishing content that interfaces at all levels of cancer research.
Stem cells in solid tumors have been identified almost two decades ago using a growing host of surface markers and their combinations. The community describes these cells with features of epithelial-mesenchymal transition and expression of stem cell markers from the embryonic stem cell field. Nevertheless, the more prominent functional features like self-renewal in vitro and in vivo, differentiation into non-stem cells or the general ability to recreate the tumor from cell one is often not assessed in depth. In this issue, we hope to provide new input on the connection of functionality and marker expression of stem cell phenotypes in a variety of solid human tumors. Therefore providing researchers with a frame of reference when adding to the growing collection of stem cells from solid cancers.
Keywords:
Cancer stem cells; Solid cancer; Stem cell phenotype; Surface markers; Epithelial-mesenchymal transition; Functional stemness in tumors; Pluripotency
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Jochen Maurer
PhD, University Hospital RWTH Aachen, Germany. His lab focuses on the cell of origin and the malignant progression of different types of cancer but in particular on breast cancer. His group isolates and characterizes cancer stem cells from these tumors and investigates molecular mechanisms of self-renewal and differentiation as well as invasion and metastasis.
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