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Natural Killer cell therapy

Participating journal: Cancer Immunology, Immunotherapy

View the webinar recording based on this Natural Killer Cell Therapy collection.

Adoptive transfer of natural killer (NK) cells has become a new paradigm in treatment of solid tumors. In contrast to cytotoxic T lymphocytes that recognize tumor antigen in the complex of MHC, NK cells target tumor cells that either have low or no MHC expression, which has been used by tumor cells to evade CTL attack. Thus, NK cell therapy can be an appropriate complemental therapy in treatment of tumors that escape CTL therapy. To that end, new strategies are needed to enhance the efficacy of the NK cell therapy. This collection will highlight studies in several key areas (but not limited in these areas) of NK cell research: (1) optimal culture and expansion method of NK cells that are aimed to maximize the clinical efficacy; (2) rational combination with targeted therapy agents, and immune checkpoint inhibitors; (3) NK cell-intrinsic factors that may directly or indirectly enhance the efficacy of NK cell therapy; (4) reports of clinical trials of NK cell therapy.

Please note this collection does not have a specific Guest Editor appointed and manuscripts are handled on a case by case basis by members of our editorial board. The peer review process for these articles is the same as the peer review process of the journal in general.

Participating journal

Submit your manuscript to this collection through the participating journal.

Cancer Immunology, Immunotherapy is providing a timely and open access publication of original discovery and developments in basic and translational research in the field of cancer...

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